Among the genes dysregulated in both rat and human adenomas, we found genes associated with pituitary function or pituitary tumorigenesis and mentioned earlier in the article, such as AR, CCNB1, DLK1, ECT2, FOS, NEUROD1, NR0B1/DAX1, VEGF. Genes encoding transcription factors and hormones important in other pituitary cell lineages (i.e. POU1F1/PIT-1, TBX19, GH, PRL, POMC) are down-regulated in rat and human gonadotroph-derived adenomas, as expected. This evidence concerns the gene POU1F1 and adenoma.