Noteworthy, in addition to NUSAP1, our meta-analysis of human PA array data has identified the up-regulation of genes encoding other proteins playing a critical role in mitosis, mitotic spindle checkpoint and dynamics, or cytokinesis such as BUB1, CCNB1, CDC2, KIF4, KIF11, PRC1, in gonadotroph adenomas (Supplementary Table 2). This evidence concerns the gene BUB1 and functioning gonadotropic adenoma.