Noteworthy, in addition to NUSAP1, our meta-analysis of human PA array data has identified the up-regulation of genes encoding other proteins playing a critical role in mitosis, mitotic spindle checkpoint and dynamics, or cytokinesis such as BUB1, CCNB1, CDC2, KIF4, KIF11, PRC1, in gonadotroph adenomas (Supplementary Table 2). The gene discussed is CCNB1; the disease is functioning gonadotropic adenoma.