IGFBP3 and adenoma: Array data mining found that genes such as Ccnb1, Igfbp3, Nusap1, Pttg1, Racgap1, Top2a, Tpx2, which are associated with the aggressive behaviour of various human tumors, including PAs, and proto-oncogenes such as Ect2, Kit, Kras, Lyn, Ret are up-regulated in rat adenomas [12, 15, 42, 43].