We have shown that TGF-β-induced-Snail not only induces metastasis-causing epithelial-to-mesenchymal transition (EMT) of cancer cells but also enhances production of immunosuppressive cytokines and chemokines, including TGF-β, IL-10, CCL2, and TSP-1 (Kudo-Saito et al., 2009), which further promotes metastasis. The gene discussed is CCL2; the disease is cancer.