TNFSF11 and Ewing sarcoma: Thus the fully human monoclonal anti-GD2 antibody (ch14.18) which targets the ganglioside GD2, that is expressed on the surface of OS and Ewing sarcoma cells and denosumab which binds and neutralizes the activity of the receptor activator of nuclear factor kappa B ligand (RANK-L) cannot be tested in mice.