Since Ezrin represents another pro-invasion marker for human CRC [17], [51], we examined the effect of km23-1 depletion on expression of this cytoskeletal linker protein in two different CRC cell models, harboring distinct KRAS mutational events [ie, codon 13 (G13D) in HCT116 cells and a G12D mutation in CBS cells [24]]. The gene discussed is CBS; the disease is colorectal carcinoma.