If the association of a high CB1 receptor expression with prostate cancer disease severity and outcome is the result of a switch to Akt-mediated signalling, certain predictions can be made: Firstly, cases with a high tumour CB1 receptor expression would be expected to have higher activity in the Akt pathway and therefore there should be a positive correlation between CB1IR scores and pAkt-IR scores in the tumour tissue. This evidence concerns the gene AKT1 and prostate cancer.