EGFR and lung cancer: Interestingly, in a variety of cell lines, THC (1 μM) and HU210 (50 nM) produce a rapid transactivation of EGFR (and in the case of THC and NCI-H292 lung cancer cells, of ErbB2) in a metalloprotease-dependent manner [40]; cannabinoid activation of Akt in the NCI-H292 cells and in SCC-9 squamous cell carcinoma cells was blocked by both EGFR- and metalloprotease inhibitors [40].