In category 2, the genes encoding nuclear factor, erythroid-derived 2 (Nfe2); hemoglobin, theta 1 (Hbq1); erythroid associated factor (Eraf); and 2,3-bisphosphoglycerate mutase (Bpgm) were down-regulated only in the case of short-term iron deficiency. This evidence concerns the gene NFE2 and nutritional disorder.