In humans, TG-rich VLDL (large VLDL1) can be a precursor of sdLDL-cho, i.e., large VLDL1 particles are converted to sdLDL particles by cholesteryl ester transport protein (CETP) and hepatic lipase (HL), the levels of which are commonly increased in type 2 diabetes [30]. The gene discussed is LIPC; the disease is type 2 diabetes mellitus.