In comparison, stimulation of GRP78 expression in response to hypoglycemia is a slow process, where GRP78 protein levels hardly increase within the first 8 hours (Figure 2); therefore, transcriptional blockage by VCD would not be able to affect the levels of GRP78 (a long-lived protein) at early time points where mitochondrial function already is impacted. Here, HSPA5 is linked to Hypoglycemia.