HSD17B10 and neurodegenerative disease: Moreover, while SDR5C1 appears to be vital for mitochondrial function, this does not appear to be due to its dehydrogenase function; mitochondrial abnormalities associated with mutations in HSD17B10 (the gene encoding human SDR5C1) do not seem to correlate with the residual dehydrogenase activity, suggesting that another function of SDR5C1 could actually be compromised and responsible for the mutation-associated neurodegenerative disease [29].