NOS2 and systemic lupus erythematosus: In contrast, administration with LV-shGRN in lupus model considerably inhibited M2b polarization, as renal macrophages from LV-shGRN-injected lupus mice performed lower mRNA levels of TNF-α, IL-1β, IL-6, IL-10, IL-12, MCP-1 and Nos2 than those of controls (Fig. 3B), confirming the reinforced effect of GRN on ALD-DNA-induced M2b polarization.