BIRC5 and neoplasm: Interestingly, a survivin-XIAP complex promotes via TGF-beta activated kinase 1 binding protein 1 (TAB1)/TGF-beta activated kinase 1 (TAK1) and subsequent Nuclear Factor kappaB (NF-κB) activation tumor cell invasion and metastasis by activation of the cell motility kinases FAK (focal adhesion kinase) and Src (sarcoma) [11].