In line with this observation, in the Leyden 85+ study, reduced responsiveness to LPS stimulation (lower TNFα, IL-1β, IL-6, IL-10 and IL-1Ra production by whole blood cells) from community-dwelling or nursing home 85-year old residents was significantly associated with a worse survival and risk factors like history of malignancies, chronic illness and elevated CRP levels [6]. The gene discussed is TNF; the disease is cancer.