Interestingly, our observed Cu2+-mediated oxidation that subsequently leads to aggregate formation is in accordance with the notion that familial ALS mutants and/or Cu2+-mediated free radical generation may be the initial event that leads to SOD1 mutant-linked protein aggregation, and mitochondrial pathology [67], and the report showing early mRNA oxidation occurs in ALS [68]. This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.