ENMD-2076 is a novel vinyl pyrimidine chemical entity actively against Aurora A and angiogenic kinases including VEGFR2, FLT3 et al. ENMD-2076 inhibited the in vitro growth of colorectal cancer, breast cancer, lung cancer, prostate cancer and leukemia cell lines with better IC50s of about hundreds nanomole [25]. Here, KDR is linked to breast cancer.