However, it is still unclear whether the reduced liver fibrosis is due to a lack of fibrogenic effects of TNF-α or due to the reduced liver injury because previous reports indicate that both liver injury and fibrosis after CBDL are reduced in TNF-α−/− mice [8] and TNFR1−/− mice [9]. Here, TNFRSF1A is linked to Hepatic fibrosis.