Moreover, our previous study has indicated that an ethanolic extract of Lindera obtusiloba stems (LOE) at a dose of 100 mg/kg/day prevented endothelial dysfunction and hypertension induced by the chronic infusion of Ang II to rats, in part, by normalizing the NADPH oxidase-dependent vascular oxidative stress [27]. This evidence concerns the gene FMO5 and endothelial dysfunction.