Since previous studies have shown that LOE prevented Ang II-induced hypertension and endothelial dysfunction in rats [27], and that increased levels of Ang II and its major receptor, Ang II type 1 receptor (AT1R), are observed in aortic sections of db/db mice [28], the possibility that LOE affects the local angiotensin system was assessed. The gene discussed is AGTR1; the disease is Hypertension.