Only one cancer gene, IKZF1, was among the most stable 10% of the 100 genes analyzed, while seven deletion-prone cancer genes, FANCA, NCOR1, BRCA1, PBRM1, ATM, FANCD2 and MSH2 were among the most unstable 10% (10) of the 100 genes analyzed (Tables S3 and S4). The gene discussed is MSH2; the disease is cancer.