REN and obesity due to melanocortin 4 receptor deficiency: 14 Goossens Goossens GH GH ,  Blaak Blaak EE EE ,  van Baak van Baak MA MA  ( 2003 2003 )  Possible involvement of the adipose tissue renin-angiotensin system in the pathophysiology of obesity and obesity-related disorders Possible involvement of the adipose tissue renin-angiotensin system in the pathophysiology of obesity and obesity-related disorders .