LEP and endothelial dysfunction: 49 Knudson Knudson JD JD ,  Dincer Dincer UD UD ,  Dick Dick GM GM ,  Shibata Shibata H H ,  Akahane Akahane R R ,  et al et al  ( 2005 2005 )  Leptin resistance extends to the coronary vasculature in prediabetic dogs and provides a protective adaptation against endothelial dysfunction Leptin resistance extends to the coronary vasculature in prediabetic dogs and provides a protective adaptation against endothelial dysfunction .