The results showed that the presence of the A-allele at CRP SNP rs7553007 (HR = 1.101; 95% CI = 1.011–1.200; P = 0.027) and KRAS/BRAF mutations (HR = 2.377; 95% CI = 1.293–4.368; P = 0.005) were independent prognostic factors in CRC patients with synchronous liver metastasis. The gene discussed is CRP; the disease is metastasis.