The activation of the mitogen-activated protein (MAP) kinase signaling pathway, especially via mutations of v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) and v-Raf murine sarcoma viral oncogene homolog B1 (BRAF), is a key step in the development of CRC [8]. This evidence concerns the gene KRAS and colorectal carcinoma.