Univariate Cox regression analysis (Table 3) revealed that the CRP SNP rs7553007 genotype (hazard ratio [HR] = 1.092; 95% confidence interval [CI] = 1.008–1.183; P = 0.030) and KRAS or BRAF mutations (HR = 2.174; 95% CI = 1.199–3.942; P = 0.011) were significantly associated with CSS in CRC patients with synchronous liver metastasis. This evidence concerns the gene KRAS and colorectal carcinoma.