Also early after the onset of diabetes, several markers of inflammation and endothelial activation including MCP-1, VCAM-1, IL-1β, Cox2 and TF were significantly increased at the mRNA level in the aortic wall of diabetic mice when compared to controls; and trends towards increased IL-6 and ICAM-1 were observed (Figure S5). This evidence concerns the gene PTGS2 and diabetes mellitus.