NFATC3 and diabetes mellitus: In a follow-up study, we demonstrated that hyperglycemia readily activated NFATc3 in the arterial wall in vivo, as evidenced by increased NFATc3 nuclear accumulation in cerebral arteries after an i.p. glucose-tolerance test and by increased NFATc3-dependent transcriptional activity in aorta 2 weeks after the induction of diabetes with STZ [6].