The ‘ZnT8Ab’-component is strongly related to a genetic profile of risk alleles of SNPs in the T1D related genes: TAF5L (rs3753886), HNF1B (rs4430796), IL2RA (rs11594656) and PTPN2 (rs1893217) in combination with the T2D associated SNP: CDKAL1 (rs10946398); and protective alleles of the T1D associated gene ERBB3 (rs2292239) (P = 0.0005) (Figure 3B (III)). This evidence concerns the gene PTPN2 and type 1 diabetes mellitus.