Furthermore, the ‘β-cell function’-component is associated with a genetic pattern of multiple number of risk alleles of T1D associated SNPs from the insulin VNTR region (INS (rs3842753 and rs689) and the RNLS (rs10509540) together with T2D associated SNPs in WFS1 (rs10010131) and CDKN2A/2B (rs564398) genes and protective alleles of the T2D associated SNP (rs7961581) in the TSPAN8-LGR5 gene (P = 0.006) (Figure 3A (III). This evidence concerns the gene RNLS and type 2 diabetes mellitus.