The investigators began with a GWAS of 2,078 CAD cases vs. 2,953 control individuals and then went on to test all SNPs that reached genome-wide significance with monocyte transcripts in cis and trans. They found associations between LIPA mRNA transcript levels and low HDL cholesterol (P = 2.5 × 10−3) as well as impaired endothelial function measured by flow-mediated vasodilation, but not with traditional risk factors, LDL cholesterol, or triglycerides. This evidence concerns the gene LIPA and coronary artery disorder.