Similarly, IL-10-dependent TH1 self-regulation is essential in restraining the immune response and preventing tissue damage in models of autoimmune disease including colitis (Suri-Payer and Cantor, 2001), RA (Hata et al., 2004), neuritis (Bai et al., 1997), SLE (Beebe et al., 2002), and uveoretinitis (Rizzo et al., 1998). The gene discussed is IL10; the disease is autoimmune disease.