IL-10 production is significantly inhibited in TH17 cell clones from CAPS patients but in vivo administration of Anakinra, an IL-1R1 antagonist, restores IL-10 secretion by IL-17A+ T cell clones (Jacobs and Ciaccio, 2010; Zielinski et al., 2012). The gene discussed is IL10; the disease is cryopyrin-associated periodic syndrome.