In Invasive Pulmonary Aspergillosis (IPA), conidia of A. fumigatus induce the PTX3 secretion in the lungs which in turn recognizes and binds to the galactomannan moieties on the conidia and facilitates its phagocytosis by macrophages (Garlanda et al., 2002). The gene discussed is PTX3; the disease is Ito hypomelanosis.