Intraperitoneally administered PTX3 decreased the concentration of inflammatory mediators such as IL-1ββ, IL-17, CCL-2/MCP-1, CXCL1/KC, and CXCL2/MIP-2 in P. aeroginosa infected CF mice as compared to untreated CF mice. This evidence concerns the gene CXCL1 and cystic fibrosis.