SLC9A1 and left ventricular hypertrophy: Moreover, Ald has been shown to activate NHE-1, (De Giusti et al., 2011) increase NHE-1 expression (Karmazyn et al., 2003) and induce left ventricular hypertrophy independently from its classical effects on regulation of renal Na+ excretion and blood pressure (Qin et al., 2003; Yoshida et al., 2005; Diez, 2008).