To evaluate if YKL-40 possesses the same angiogenic activity in cancer, a breast cancer line MDA-MB-231 and colon cancer lines HCT-116 and SW480 were engineered to express ectopic YKL-40 (Shao et al., 2009; Kawada et al., 2012). The gene discussed is CHI3L1; the disease is breast carcinoma.