For instance, individual anti-angiogenic treatment with bevacizumab (anti-VEGF antibody, Avastin), DC101 (anti-VEGF receptor antibody), or sunitinib (anti-VEGF receptor kinase inhibitor) can elicit vascular rebound and tumor cell invasiveness and metastasis in several animal models (Casanovas et al., 2005; Ebos et al., 2009; Paez-Ribes et al., 2009). Here, VEGFA is linked to neoplasm.