Interestingly, strong expression levels of YKL-40 were identified in TAMs in both breast cancer and lung cancer, as these TAMs surrounding tumor cells co-expressed YKL-40 and CD68, a marker of macrophages (Junker et al., 2005a,b; Roslind et al., 2007a; Stearman et al., 2008). This evidence concerns the gene CHI3L1 and neoplasm.