Although the overall pathological role and molecular mechanisms of YKL-40 in tumorigenesis remain to be established, an angiogenic feature has been reported to regulate tumor development in breast cancer, colon cancer, and GBM (Shao et al., 2009; Francescone et al., 2011; Kawada et al., 2012). This evidence concerns the gene CHI3L1 and malignant colon neoplasm.