VEGFA and neoplasm: The signaling activation by YKL-40 in endothelial cells was similarly identified in the tumor line U87 cells, in which YKL-40 induces strong association of syndecan-1 with different integrin αvβ5 and downstream activation of FAK397 and Erk 1 and 2, thus targeting VEGF expression that evokes endothelial cell angiogenesis (Francescone et al., 2011).