CHI3L1 and neoplasm: For example, YKL-40-directed gene knockdown in GBM-derived U87 cells notably suppressed tumor angiogenesis, as the vessel density of YKL-40 shRNA tumors was decreased to 44% of vasculature relative to control tumors and tumor volume was accordingly reduced to approximately 30% of control counterparts (Shao et al., 2009).