The CRF system may affect social behaviors via a broader role in stress, anxiety, depression, and adaptation (Dunn and Berridge, 1990; Heinrichs et al., 1995; Arborelius et al., 1999; Koob and Heinrichs, 1999; Radulovic et al., 1999; Bale and Vale, 2004; Ryabinin et al., 2012), but there is also support that the CRF system specifically modulates social behaviors. The gene discussed is CRH; the disease is major depressive disorder.