In contrast, rdgB2 requires both, whereby (1) rdgB2 flies fail to degenerate in complete darkness [44], (2) the rdgB2 retinal degeneration is rescued by norpAP24[44], and (3) the rdgBKS222 retinal degeneration is rescued by trp1[38]. Here, PITPNM2 is linked to retinal degeneration.