One of the B12-associated loci, FUT2, has previously been associated with reduction in liver enzymes including alkaline phosphatase (ALP) [33] and cholesterol levels [34], increased risk of Crohn's disease [35], [36], psoriasis [37], retinal vascular caliber [38] and type 1 diabetes [39] and protection against Norovirus infection [40]. This evidence concerns the gene FUT2 and Crohn disease.