MTHFR and Stroke: As outlined in Table S10, variants associated with serum B12 or folate levels did not consistently affect the risk of the diseases tested; the B12 or folate increasing allele for some variants was weakly protective and for others weakly at risk, and only two loci (CUBN associated with CAD and MTHFR with stroke) were statistically significant (P<0.0018) but with opposite effects on these diseases.