Furthermore, two bladder cancer risk variants in the 5p15 were discovered including rs2736098, a synonymous variant located in the exon of the TERT gene and rs401681 in intron 4 of CLPTM1L. Additionally, both variants were found to be associated with increased risk of basal cell carcinoma, lung cancer and cervical cancer, which are known to be strongly connected to environmental exposures. Here, CLPTM1L is linked to lung cancer.