CLPTM1L and urinary bladder carcinoma: Furthermore, two bladder cancer risk variants in the 5p15 were discovered including rs2736098, a synonymous variant located in the exon of the TERT gene and rs401681 in intron 4 of CLPTM1L. Additionally, both variants were found to be associated with increased risk of basal cell carcinoma, lung cancer and cervical cancer, which are known to be strongly connected to environmental exposures.