RAC1 and metastatic malignant neoplasm in the lymph nodes: Statistically significant correlations were found between high Rac1/Cdc42 expression and advanced TNM staging (P<.001), proliferation index (Ki67 status; P<.001), ER status (P<.001), and positive invasive features, including lymph node metastasis (P<.001) and tumor invasion (P<.001) (Table 1).