For instance, human pluripotent stem cells maintain high glycolytic rates with high levels of hexokinase II and inactive pyruvate dehydrogenase [53].Thus, it is possible that the high Hex activity we observe during the first hours of T. castaneum embryonic development drives G6P to several biochemical pathways including the pentose pathway or aerobic glycolysis like it has been described for tumor cells. The gene discussed is HHEX; the disease is neoplasm.