Furthermore, the fact that the 323 peptide induced T cells that make IFN-γ but showed poor lytic activity, whereas the 323-3F peptide induced T cells with slightly improved IFN-γ production but much greater lytic activity suggests that the POTE 323-3F peptide induces a response that is improved in quality as well as quantity and can kill human tumor cells expressing endogenously processed wild type POTE. This evidence concerns the gene IFNG and neoplasm.