In our functional studies we demonstrate co-localization of LRRTM3, APP and BACE1 in early endosomes of human neuroblastoma cells; co-localization of LRRTM3 and APP in cell body and processes of primary neurons from Tg2576 mouse model [18] and co-IP of LRRTM3 with BACE1 and endogenous APP from HEK293T cells. The gene discussed is LRRTM3; the disease is neuroblastoma.