Among urological cancers, low TSP-1 expression was significantly associated with positive p53 status in RCC [74,98], bladder cancer [80], and prostate cancer [69], but several studies have reported that there was no significant correlation between TSP-1 expression and p53 status in prostate cancer [61,63] and urothelial cancer [82]. This evidence concerns the gene THBS1 and urinary bladder cancer.