IGF2 and ovarian cancer: Insulin-like growth factor-II (IGF2) encodes a potent autocrine and paracrine mitogen that is important to early growth and development (Hoyo et al., 2012; St-Pierre et al., 2012), but is also often deregulated in cancers, including colon (Cui et al., 2003) and ovarian cancers (Sayer et al., 2005; Lu et al., 2006; Murphy et al., 2006; Dammann et al., 2010; Qian et al., 2011) where it has been shown to modulate taxol response (Huang et al., 2010).