Nal et al. (2007) found that isoform 1 of Myosin-XV, which includes the N-terminal extension, is required for hearing in humans, based on their identification of 16 recessive NSHL mutations in human MYO15A. Further study is required to quantify the extent of positive selection occurring and its precise location within this gene. This evidence concerns the gene MYO15A and nodular sclerosis classical Hodgkin lymphoma.