Microscopically, CTE typically features tau-positive NFTs and astrocytic tangles, and neuropil neurites in a distribution distinctly different from other tauopathies such as Progressive Supranuclear Palsy, Corticobasal degeneration, and Alzheimers' Disease (AD) (McKee et al., 2009; Omalu et al., 2011). The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.