[29, 30] Following our first demonstration of LH-RH receptors in pancreatic cancers in 1989, several other groups have confirmed that receptors for LH-RH are present in pancreatic tumors [15, 21] Based on these findings, in the present study, we investigated the effects of cytotoxic LH-RH analog AN-152 (AEZS-108), consisting of [D-Lys6]LH-RH linked to DOX-14-O-hemiglutarate on various human pancreatic cancers in nude mice. The gene discussed is GNRH1; the disease is familial pancreatic carcinoma.