TP53 and neoplasm: To prove the general significance of the observed phenotype across different tumor entities, the hematopoietic T cell leukemia cell line CEM was additionally studied, which expresses mutant but functionally active p53.11, 18, 23, 24, 28 siRNA against cyclinB and E arrested the cell cycle in G2 and G1, respectively, also to a minor extent compared with the solid tumor cell lines (Supplementary Figure S6A).