We have recently described the importance of p53-mediated cell cycle arrest for inhibiting vinca alkaloid-induced apoptosis.18 We also described that TRAIL damages stem cell surrogates in patient-derived leukemia cells.19 As cancer stem cells are often resting, we hypothesized that TRAIL might be able to induce apoptosis in resting tumor cells. This evidence concerns the gene TNFSF10 and neoplasm.