Induction of melanoma cell death by HDAC inhibitors or blockade of the RAF/MEK/ERK pathway is associated with the up-regulation of Bim and the downregulation of Mcl-1.10, 19, 21 We have also shown previously that the combination of SAHA and PLX4720 further upregulates BimEL. This evidence concerns the gene HDAC9 and melanoma.