Our past results have suggested that sensitivity to induction of cell death may be a major determinant of long-term responses of BRAFV600E melanoma cells to BRAF inhibitors.10 Killing of melanoma cells by BRAF or MEK inhibitors involves regulation of anti- and prosurvival proteins of the Bcl-2 family, in particular, Bim and Mcl-1.17, 18, 19, 20 However, induction of melanoma cell death by inhibition of MEK has been shown to be caspase-independent, although the caspase cascade is activated upon MEK inhibition in sensitive cells.21 The gene discussed is BCL2; the disease is melanoma.