Although we and others have previously found that upregulation of Bim is important for killing of sensitive melanoma cells by inhibition of the MEK/ERK pathway,10, 17, 21 our results in this study showed that involvement of Bim is, at least in some BRAFV600E melanoma cell lines, dispensable for induction of cell death by cotreatment with SAHA and PLX4720. This evidence concerns the gene BCL2L11 and melanoma.