BRAF and melanoma: Consistent with our previous reports that the HDAC inhibitor SAHA and the BRAF inhibitor PLX4720 synergistically kill BRAFV600E melanoma cells (MM200, IgR3, and Mel-RMu cells),36 cotreatment with SAHA and PLX4720 cooperatively killed Mel-CV and Sk-Mel-28 cells that also harbored BRAFV600E, as measured using CellTiter-Glo assays (Figure 1a).34, 35 In contrast, the combination did not impinge on survival of cultured human melanocytes (HEMn-MP cells) (Figure 1a).