Overexpression of Mcl-1 inhibited, albeit partially, reduction in cell viability in MM200, Sk-Mel-28, Mel-RMu, and IgR3 cells (Figures 2c and d), suggesting that downregulation of Mcl-1 contributes to synergistic killing of BRAFV600E melanoma cells by the inhibitors irrespective of whether Bim is involved. The gene discussed is MCL1; the disease is melanoma.