BRAF and melanoma: The above results extend our previous finding that HDAC and BRAF inhibitors synergistically induce cell death of BRAFV600E melanoma cells by showing that, although the combination triggers activation of the caspase cascade and the mitochondrial apoptotic signaling, it kills BRAFV600E melanoma cells primarily by induction of necrosis through a mechanism that is independent of RIPK1 and RIPK3.