In a multicenter study (five institutions) of 120 patients with endometrial cancer who met criteria A (one or more first-degree relatives with a Lynch syndrome-related cancer: colorectal, endometrial, small intestinal, ureteral or renal pelvis, gastric, ovarian or breast cancer; and one or more cancer diagnosed before the age of 50 years old) or criteria B (patients with two or more Lynch syndrome-related cancers), Hirai et al. [36] found 18 patients with MMR gene abnormalities and nine with MSH6 mutations. This evidence concerns the gene MRC1 and breast carcinoma.