Although the complete role of hyperglycemia in the pathogenesis of cardiovascular diseases (CD) is still speculative, relevant studies, such as the The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study, have shown advantages to glycemic control through intensified insulin treatment for a reduction in macrovascular events. Here, INS is linked to Hyperglycemia.