A systematic review of publications, which evaluated the accuracy and reliability of serum and urinary biomarkers in human subjects when used to diagnose the established AKI or early AKI, or to risk stratify patients with AKI, indicated that serum cystatin C (CysC), urine interleukin-18 (IL-18), and urine kidney injury molecule-1 (KIM-1) performed best for the differential diagnosis of established AKI. The gene discussed is IL18; the disease is acute kidney injury.