SLC30A10 and Alzheimer disease: Given the known link between neurological conditions and chronic exposure to Mn, it is possibile that the dys-homeostasis of ZnT10 observed in the AD brain is related to changes in levels of Mn rather than Zn., Mechanisms of Mn-induced neurological changes remain to be elucidated, although oxidative stress, protein aggregation or altered homeostatic conditions of other divalent metals that share similar transport mechanisms have been suggested [13].