As expected from an earlier study [5], after 3 daily i.p. injections of TAA (485 mg/kg), clear signs of hepatic failure with significant increases in ALT (5.8 - fold) and AST (4.6 - fold) (Table 1), together with increased necrosis of hepatocytes were observed in transgenic mice (Figures 1A, a, B and b). Here, GPT is linked to Hepatic failure.