The depression effect of DDX5 knockdown on p24 production in the presence of wild-type HIV-1 infection (Fig. 1F, top panel) is only 30%, which could be due to input of wild-type HIV-1 is relatively high and the knockdown efficiency of DDX5 by exogenous siRNA in primary human CD4+T cells is not good (only ∼27% decrease) (Fig. 1F, bottom panel). Here, CD4 is linked to HIV-1 infection.