Interestingly, in the right ventricle of both INF and INF-HF animals, a late remodeling process seems to be also present, since it was observed a reduction in both MMP-2/TIMP-2 ratio (mainly due to a reduction in MMP-2 expression) and collagen I mRNA, as well as an increase in LOX expression. This evidence concerns the gene TIMP2 and hydrops fetalis.