The eccentric remodeling was also accompanied by fibrosis in the HF group, The mechanisms involved in the LV fibrosis that starts soon after ischemic injury are still present after 30 days since was found an increase in collagen production, as suggested by the increase in gene expression of collagen as well of the profibrotic factors CTGF and TGF-β. The gene discussed is CCN2; the disease is hydrops fetalis.