Calcium is an important factor in the process of migration [7]; studies from our laboratory show that the Transient Receptor Potential channel TRPV2 is expressed in the metastatic PCa cell lines, including PC-3 cells, and trpv2 transcript levels are 12 times higher in patients with metastatic cancer (stage M1) compared with primary solid tumors (stages T2a and T2b). This evidence concerns the gene TRPV2 and posterior cortical atrophy.