TRPV2 and metastatic malignant neoplasm: Calcium is an important factor in the process of migration [7]; studies from our laboratory show that the Transient Receptor Potential channel TRPV2 is expressed in the metastatic PCa cell lines, including PC-3 cells, and trpv2 transcript levels are 12 times higher in patients with metastatic cancer (stage M1) compared with primary solid tumors (stages T2a and T2b).