HSD17B12 and neoplasm: FASN inhibition led to down-regulation of PLA2G4A and HSD17B12 genes, encoding phospholipase A2 and17-β hydroxysteroid dehydrogenase, respectively, which are key enzymes in production of intracellular second messenger arachidonic acid and androgen hormones, both playing roles in promotion of tumor progression [19], [20].