We have previously reported uptake mechanism of radiolabeled acetate into tumor cells; cytosolic acetyl-CoA synthetase, which converts acetate to acetyl-CoA, is over-expressed in tumor cells and plays a role in incorporation of radiolabeled acetate and the acetate incorporated into tumor cells is mainly used for fatty acid synthesis rather than breakdown to CO2 via tricarboxylic acid cycle or amino acid synthesis [7], [8]. This evidence concerns the gene ACSS2 and neoplasm.